Title of article :
Efficient synthesis of isoplagiochin D, a macrocyclic bis(bibenzyls), by utilizing an intramolecular Suzuki–Miyaura reaction
Author/Authors :
Esumi، نويسنده , , Tomoyuki and Wada، نويسنده , , Mitsumasa and Mizushima، نويسنده , , Eri and Sato، نويسنده , , Norimasa and Kodama، نويسنده , , Mitsuaki and Asakawa، نويسنده , , Yoshinori and Fukuyama، نويسنده , , Yoshiyasu، نويسنده ,
Abstract :
Isoplagiochin D, a highly strained macrocyclic bis(bibenzyls) with two biaryl units isolated from the liverwort Pladiochila fruticosa, was prepared in 10.6% overall yield for the 11 steps by an efficient synthetic approach involving the construction of two bibenzyl and one biaryl units using Horner–Wadsworth–Emmons and Suzuki–Miyaura protocols.
