Title of article :
Synthesis of β-hydroxy nitriles and 1,3-amino alcohols from epoxides using acetone cyanohydrin as a LiCN precursor
Author/Authors :
Ciaccio، نويسنده , , James A. and Smrtka، نويسنده , , Michael and Maio، نويسنده , , William A. and Rucando، نويسنده , , David، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Abstract :
The reaction of acetone cyanohydrin with MeLi affords a LiCN·acetone complex that can be made to react with epoxides in THF, either in one-pot or using isolated samples of the cyanide complex, to cleanly afford β-hydroxy nitriles upon aqueous workup; in situ hydride reduction of nitriles affords 1,3-amino alcohols.
Keywords :
?-Hydroxy nitrile , epoxide , Anhydrous conditions , One-pot , Lithium cyanide , amino alcohol
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
