Title of article
First examples of tetracyclic triterpenoids with a D:B-friedobaccharane skeleton. A tentative biosynthetic route
Author/Authors
Nٌْez، نويسنده , , Marvin J. and Lَpez، نويسنده , , Manuel R. and Jiménez، نويسنده , , Ignacio A. and Moujir، نويسنده , , Laila M. and Ravelo، نويسنده , , Angel G. and Bazzocchi، نويسنده , , Isabel L.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
7367
To page
7370
Abstract
Baruol (1) and Leonal (2), first examples of tetracyclic triterpenes possessing a D:B-friedobaccharane skeleton, were isolated from Maytenus blepharodes and M. chiapensis, respectively. Their structures were established by spectroscopic analysis, molecular modeling studies and biogenetic background. The implication of the D:B-friedobaccharenyl cation in the biosynthetic route of baccharane and shionane skeletons is discussed. Baruol exhibited β-glucuronidase inhibitory activity, a target in the search for hepatoprotective agents.
Keywords
Tetracyclic triterpenoids , D:B-friedobaccharanes , Celastraceae , Biosynthetic route
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1843390
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