Title of article :
A synthesis of 17-epi-calcidiol
Author/Authors :
Kurek-Tyrlik، نويسنده , , Alicja and Michalak، نويسنده , , Karol and Urbanczyk-Lipkowska، نويسنده , , Zofia and Wicha، نويسنده , , Jerzy، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Abstract :
The first synthetic approach to 17-epi-calcidiol 4 and congeners is presented. Key steps of the synthesis involve Pd-catalyzed reaction of the androst-16-ene derivative 6 with alkyl diazoacetates producing the respective cyclopropane derivatives 5, and lithium in liquid ammonia reduction of 5 leading to 17α-pregnane-20-carboxylic acid derivatives 9. The side chain was attached to ester 19 in a known manner.
Keywords :
Lithium in liquid ammonia , Vitamin D synthesis , Cyclopropanation , Alkyl diazoacetates
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
