Author/Authors :
Yu، نويسنده , , Yongping and Ostresh، نويسنده , , John M. and Houghten، نويسنده , , Richard A.، نويسنده ,
Abstract :
A solid-phase synthesis of 5-aminotetrazoles is described. Resin-bound thioureas were displaced by sodium azide in the presence of HgCl2 and following nucleophilic cyclization produced the resin-bound products. The desired 5-aminotetrazoles were cleaved from the resin using 95% trifluoroacetic acid in dichloromethane in good yield and purity.
