Title of article
Synthesis and properties of novel base-discriminating fluorescent (BDF) nucleosides: a highly polarity-sensitive fluorophore for SNP typing
Author/Authors
Saito، نويسنده , , Yoshio and Miyauchi، نويسنده , , Yohei and Okamoto، نويسنده , , Akimitsu and Saito، نويسنده , , Isao، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
5
From page
7827
To page
7831
Abstract
We have developed novel alkanoylpyrene-labeled BDF nucleosides, AMPyU and MPyU. These nucleosides exhibit strong fluorescence emission at long wavelength that is highly sensitive to solvent polarity. BDF probes containing AMPyU selectively emit fluorescence only when the base opposite BDF nucleoside is adenine and act as effective reporter probes for homogeneous SNP typing.
Keywords
fluorescence , oligodeoxynucleotide , Pyrene , BDF
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1843558
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