Author/Authors :
Shimizu، نويسنده , , Hitoshi and Shimizu، نويسنده , , Kazuki and Uchiyama، نويسنده , , Yasushi and Sugita، نويسنده , , Atsuko and Mikami، نويسنده , , Tetsuhiro and Yamauchi، نويسنده , , Tsuyoshi and Kato، نويسنده , , Masahiro and Morikawa، نويسنده , , Kazumi، نويسنده ,
Abstract :
Two 21-nor-22-oxa-1α,25-dihydroxyvitamin D3 derivatives have been synthesized in quest of a drug with lower calcemic activity than Maxacalcitol, 22-oxa-1α,25-dihydroxyvitamin D3, being used as antihyperparathyroidism and antipsoriatic drug. Of two 21-nor products obtained, the product carrying one carbon elongated side chain with diethylcarbinol moiety has been found to exhibit comparable differentiation-inducing activity to Maxacalcitol with much lower exhibition of calcemic activity.
Keywords :
Vitamin D3 derivative , 22-Oxavitamin D3 derivatives , Separation of activity , Differentiation-inducing activity , Calcemic activity
