Author/Authors :
Saito، نويسنده , , Fumiyo and Takeuchi، نويسنده , , Ryo and Kamino، نويسنده , , Tomoyuki and Kuramochi، نويسنده , , Kouji and Sugawara، نويسنده , , Fumio and Sakaguchi، نويسنده , , Kengo and Kobayashi، نويسنده , , Susumu and Tsuda، نويسنده , , Masashi and Kobayashi، نويسنده , , Jun’ichi، نويسنده ,
Abstract :
A total synthesis of the proposed structure of plakevulin A was accomplished. However, the NMR spectral data of the synthetic plakevulin A were not identical of those of the reported compound. We next converted the synthetic plakevulin A into 1-dihydrountenone A. The 1H and 13C NMR spectral data of 1-dihydrountenone A were identical with those of reported plakevulin A except for the peaks derived from levulinic acid. Thus, we repurified sample of the natural product and confirmed that the natural sample contained 1-dihydrountenone A and levulinic acid in the ratio of one to one. We also found that not plakevulin A but 1-dihydountenone A possessed the inhibitory activity against mammalian DNA polymerases α and β.
