Author/Authors :
Saksena، نويسنده , , Anil K. and Girijavallabhan، نويسنده , , Viyyoor M. and Wang، نويسنده , , Haiyan and Lovey، نويسنده , , Raymond G. and Guenter، نويسنده , , Frank and Mergelsberg، نويسنده , , Ingrid and Puar، نويسنده , , Mohinder S.، نويسنده ,
Abstract :
Addition of ethyl Grignard reagent to the formyl hydrazone 11 via in situ silylation provided the corresponding formyl hydrazine with excellent diastereoselectivity in favor of the desired S,S-diastereoisomer 6. Treatment of 6 with the phenyl carbamate 13 efficiently provided the O-benzyl protected Noxafil, which was deprotected to provide NoxafilR.
