Author/Authors :
Noma، نويسنده , , Hisashi and Tanaka، نويسنده , , Hideya and Noguchi، نويسنده , , Hiroshi and Shibuya، نويسنده , , Masaaki and Ebizuka، نويسنده , , Yutaka and Abe، نويسنده , , Ikuro، نويسنده ,
Abstract :
A convergent synthesis provided a C25 and a C35 oxidopolyprene in which a farnesyl C15 unit is connected in a head-to-head fashion to a geranyl C10 or a geranylgeranyl C20 unit. When incubated with recombinant β-amyrin synthase from Pisum sativum the C25 oxidopolyprene was enzymatically converted to an unnatural novel tetracyclic sesterterpene, while the C35 analogue did not afford any cyclization product.
Keywords :
Unnatural sesterterpene , ?-Amyrin synthase , Oxidosqualene cyclase , triterpene synthase
