Title of article
Enzymatic formation of an unnatural novel tetracyclic sesterterpene by β-amyrin synthase
Author/Authors
Noma، نويسنده , , Hisashi and Tanaka، نويسنده , , Hideya and Noguchi، نويسنده , , Hiroshi and Shibuya، نويسنده , , Masaaki and Ebizuka، نويسنده , , Yutaka and Abe، نويسنده , , Ikuro، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
3
From page
8299
To page
8301
Abstract
A convergent synthesis provided a C25 and a C35 oxidopolyprene in which a farnesyl C15 unit is connected in a head-to-head fashion to a geranyl C10 or a geranylgeranyl C20 unit. When incubated with recombinant β-amyrin synthase from Pisum sativum the C25 oxidopolyprene was enzymatically converted to an unnatural novel tetracyclic sesterterpene, while the C35 analogue did not afford any cyclization product.
Keywords
Unnatural sesterterpene , ?-Amyrin synthase , Oxidosqualene cyclase , triterpene synthase
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1843758
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