Author/Authors :
Bose، نويسنده , , Ajay K. and Pednekar، نويسنده , , Suhas and Ganguly، نويسنده , , Subhendu N. and Chakraborty، نويسنده , , Goutam and Manhas، نويسنده , , Maghar S.، نويسنده ,
Abstract :
Grindstone Chemistry––a greatly evolved version of Toda’s method of grinding solids together for solvent-free chemical reactions––has been described and its usefulness illustrated by the successful application of this technique to a simplified process for conducting the multi-component Biginelli reaction for the synthesis of physiologically active tetrahydropyrimidinones.
Keywords :
Tetrahydropyrimidinone , Reaction by grinding , solvent-free reaction , p-TSA as an acid catalyst
