Author/Authors :
Wang، نويسنده , , Xin and Chen، نويسنده , , Ying and Crockett، نويسنده , , Richard and Briones، نويسنده , , Jorge and Yan، نويسنده , , Tony and Orihuela، نويسنده , , Carlos and Zhi، نويسنده , , Benxin and Ng، نويسنده , , John، نويسنده ,
Abstract :
Two racemic isomeric dihydronaphthalenes 1 and 2 were prepared from commercially available 5-hydroxytetralone in five linear steps. A key palladium-catalyzed double bond migration led to the synthesis of both isomers from the same starting material. Preparative chiral HPLC separation provided the enantiomerically pure materials. An asymmetric synthesis employing CBS reduction to furnish 1 was also developed.
