Author/Authors :
Liotta، نويسنده , , Lisa A. and Medina، نويسنده , , Irene and Robinson، نويسنده , , Jennifer L. and Carroll، نويسنده , , Chris L. and Pan، نويسنده , , Po-Shen and Corral، نويسنده , , Ricardo and Johnston، نويسنده , , Jennifer V.C. and Cook، نويسنده , , Kristina M. and Curtis، نويسنده , , Fiona A. and Sharples، نويسنده , , Gary J. and McAlpine، نويسنده , , Shelli R.، نويسنده ,
Abstract :
Described are the syntheses of 15 macrocyclic peptides designed to trap Holliday junctions (HJs) in bacteria during site-specific and homologous recombination. This leads to inhibiting bacterial growth. These second generation macrocycles were based on the C-2 symmetrical HJ. They were synthesized using a strategy that permits elucidation of the amino acid role in binding HJs. The syntheses of these macrocycles are an important step in the development of a new class of antibiotics.
Keywords :
Macrocycles , antibiotics , C-2 symmetrical , holliday junction , Peptides , macrocyclic peptides
