Title of article
Development of silicon-tethered anionic reaction and its application to the synthesis of chiral A-ring moieties of Taxol™
Author/Authors
Iwamoto، نويسنده , , Mitsuhiro and Miyano، نويسنده , , Masayuki and Utsugi، نويسنده , , Masayuki and Kawada، نويسنده , , Hatsuo and Nakada، نويسنده , , Masahisa، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
5
From page
8647
To page
8651
Abstract
Silicon-tethered intramolecular nucleophilic additions of a hydroxymethyl unit to ketones in β-hydroxyketones have been developed. The product obtained by this protocol was successfully converted to chiral A-ring moieties of Taxol™. Also developed was a promising silicon-tethered intramolecular α-alkylation reaction of the cyclic hydroxyketone.
Keywords
Intramolecular reaction , Alkylation , Silicon tethered , nucleophilic addition , Carbanion , Taxol™
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1843904
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