Title of article
First total synthesis of 7(S),16(R),17(S)-Resolvin D2, a potent anti-inflammatory lipid mediator
Author/Authors
Rodr??guez، نويسنده , , Ana R. and Spur، نويسنده , , Bernd W.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
8717
To page
8720
Abstract
The first total synthesis of 7(S),16(R),17(S)-Resolvin D2, a lipid mediator derived from docosahexaenoic acid, has been achieved. The key features of our synthetic strategy encompass a Co-salen hydrolytic kinetic resolution of a terminal epoxide combined with a chiral pool strategy.
Keywords
Hydrolytic kinetic resolution , Resolvins , palladium catalyst , Takai reaction , Reduction
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1843928
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