Author/Authors :
Ball، نويسنده , , Matthew and Baron، نويسنده , , Anne and Bradshaw، نويسنده , , Benjamin and Omori، نويسنده , , Hiroki and MacCormick، نويسنده , , Somhairle and Thomas، نويسنده , , Eric J.، نويسنده ,
Abstract :
A synthesis of the C(1)–C(16) fragment of the brysostatins has been developed. Key steps are the stereoselective copper(I) catalysed addition of allylmagnesium bromide to an alkynyl ester, a condensation of a βγ-unsaturated aldehyde with a ketophosphonate, and the formation of the B-ring under mild conditions by stereoselective intramolecular conjugate addition.
