Author/Authors :
Abe، نويسنده , , Kazuyuki and Kato، نويسنده , , Koji and Arai، نويسنده , , Tadamasa and Rahim، نويسنده , , Mohammad Abdur and Sultana، نويسنده , , Israt and Matsumura، نويسنده , , Shuichi and Toshima، نويسنده , , Kazunobu، نويسنده ,
Abstract :
The stereoselective and convergent synthesis of the C12–C28 segment 2 of the apoptosis inducing macrolide antibiotic, apoptolidin (1), is described. The synthesis involves a highly stereoselective tin(II)-mediated aldol reaction between the C17–C22 ethyl ketone 3 and the C23–C28 aldehyde 4 as the key step.
Keywords :
apoptolidin , macrolide , apoptosis , antibiotic , aldol reaction
