Title of article
Syntheses of morpholine-2,3-diones and 2-hydroxymorpholin-3-ones: intermediates in the synthesis of aprepitant
Author/Authors
Nelson، نويسنده , , Todd D. and Rosen، نويسنده , , Jonathan D. and Brands، نويسنده , , Karel M.J. and Craig، نويسنده , , Bridgette and Huffman، نويسنده , , Mark A. and McNamara، نويسنده , , James M.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
8917
To page
8920
Abstract
The preparation of morpholine-2,3-diones and 2-hydroxymorpholin-3-ones from N-substituted β-amino alcohols is reported. These were useful intermediates in the synthesis and development of aprepitant.
Keywords
3-diones , Lactam , Morpholine-2 , amino alcohols , Morpholine-3-ones , lactol
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1844008
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