Three-component condensations of aldehydes with N-methoxycarboxamides

The first condensations of N-methoxycarboxamides (component A) with aliphatic acetals (component B) are described. Depending upon the conditions, the hemiaminal type products (AB) can usually be isolated. Conducting the condensations with 2 equiv of acetal affords β-(N-methoxy)amido aldehydes (type ABB products). A condensation using anisole (component C) afforded a product of type ABC.