Title of article
An improved protocol for the SmI2-promoted C-alkylation of peptides: degradation and functionalization of serine residues in linear and cyclic peptides
Author/Authors
Blakskjوr، نويسنده , , Peter and Gavrila، نويسنده , , Adina and Andersen، نويسنده , , Lisbeth and Skrydstrup، نويسنده , , Troels، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
9091
To page
9094
Abstract
The utility of the samarium diiodide promoted C-alkylation of peptides for the introduction of new side chains on peptide strands is dramatically enhanced by the initial oxidative degradation of serine residues in small peptides. In this way, cyclic peptides may also be included in this repertoire as a method for the preparation of peptide libraries.
Keywords
Peptides , serine , Oxidative Degradation , Samarium diiodide , C-alkylation
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1844080
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