Title of article
Diastereoselective synthesis of the 19-epi-C18–C25 segment of (−)-lasonolide A and an unusual inversion at C19
Author/Authors
Yoshimura، نويسنده , , Tomoyuki and Bando، نويسنده , , Toshikazu and Shindo، نويسنده , , Mitsuru and Shishido، نويسنده , , Kozo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
9241
To page
9244
Abstract
Diastereoselective construction of the 19-epi-C18–C25 segment of (−)-lasonolide A was achieved using a 5-exo-trigonal mode of radical cyclization for the creation of the contiguous quaternary and tertiary stereogenic centers at C22 and C23 as the key reaction step. During the dehydration stage, it was found that an unusual inversion of configuration took place.
Keywords
Lasonolide A , radical cyclization , inversion , Polyketide , Tamao oxidation
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1844139
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