Title of article
Ruthenium-catalyzed cyclization of 3-en-1-ynyl imines with nucleophiles via tandem 5-exo-dig cyclization and nucleophilic addition
Author/Authors
Shen، نويسنده , , Hung-Chin and Li، نويسنده , , Chia-Wen and Liu، نويسنده , , Rai-Shung Liu، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
3
From page
9245
To page
9247
Abstract
Treatment of 3-en-1-ynyl imines with TpRuPPh3(CH3CN)2PF6 catalyst (1 mol %) in DCE (50 °C, 6 h) effected catalytic cyclization with suitable nucleophiles and gave functionalized pyrroles in good yields. The reaction mechanism is proposed to proceed via (2-pyrrolyl)carbenoid intermediates derived from 5-exo-dig cyclization. This catalytic reaction works well with various nucleophiles, including water, alcohols and anilines.
Keywords
cyclization , imines , nucleophile
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1844141
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