Title of article :
Structure tuning of lithium amide for asymmetric 1,4-addition to cinnamate and subsequent demasking
Author/Authors :
Sakai، نويسنده , , Takeo and Doi، نويسنده , , Hirohisa and Kawamoto، نويسنده , , Yoshito and Yamada، نويسنده , , Ken-ichi and Tomioka، نويسنده , , Kiyoshi، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Abstract :
Systematic structure tuning of lithium amides derived from benzyl-N-TMS-, allyl-N-TBDMS-, and diisopropylamines lead to several candidates including anthracen-9-ylmethanamine which provided high performance in the enantioselective 1,4-addition (91% ee) and following hydrogenolysis with 10% Pd/C-H2 in methanol to afford β-amino ester.
Keywords :
asymmetric conjugate addition , chiral ligand , Hydrogenolysis , Lithium amide , Amino acid
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
