Author/Authors :
Boyd، نويسنده , , Ewan and Coumbarides، نويسنده , , Gregory S. and Eames، نويسنده , , Jason and Hay، نويسنده , , Alastair and Jones، نويسنده , , Ray V.H. and Stenson، نويسنده , , Rachel A. and Suggate، نويسنده , , Michael J.، نويسنده ,
Abstract :
The synthesis of enantiomerically enriched (R)-2-methyl-1-tetralone 1 (64% e.e.) was achieved through protonation of its lithium enolate 3 using a C2-symmetrical bis-sulfonamide 5d as an internal proton source. Access to the complementary (S)-enantiomer 1 (45% e.e.) can be achieved using an external quench strategy involving acetic acid as the external proton source.
