Author/Authors :
Chng، نويسنده , , Shu-Sin and Hoang، نويسنده , , Truong-Giang and Wayne Lee، نويسنده , , Wei-Woon and Tham، نويسنده , , Mun-Pun and Ling، نويسنده , , Hui Yvonne and Loh، نويسنده , , Teck-Peng، نويسنده ,
Abstract :
AG7088 was identified as a good starting point for modification, leading to an efficient and bio-available inhibitor for the SARS coronavirus main proteinase (SARS-CoV Mpro). Synthesis of intermediate 1 and analogues proceeded via a highly diastereoselective indium-mediated allylation of α-aminoaldehydes.
Keywords :
AG7088 , Indium-mediated allylation , diastereoselective , Anti-SARS agents
