Title of article
Synthesis of ortho-substituted cyanopyridines through lithio intermediate trapping
Author/Authors
Cailly، نويسنده , , Thomas and Fabis، نويسنده , , Frédéric and Lemaître، نويسنده , , Stéphane and Bouillon، نويسنده , , Alexandre and Rault، نويسنده , , Sylvain، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
3
From page
135
To page
137
Abstract
Ortholithiation of 4-cyanopyridine using 2,2,6,6-tetramethylpiperidide (LiTMP) and trapping the lithio intermediate with electrophiles represents an efficient and straightforward access to ortho-substituted-4-cyanopyridines. The cyano group can be used as an ortho-directing group and allows the preparation of 3-halogeno-4-cyanopyridines. Reactivity of 2- and 3-cyanopyridines is also investigated and seems to give similar results.
Keywords
Ortholithiation , electrophile , cyanopyridine , ortho-Substituted pyridine
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1844368
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