Title of article :
Facile air oxidation of the conjugate base of rofecoxib (Vioxx™), a possible contributor to chronic human toxicity
Author/Authors :
Reddy، نويسنده , , Leleti Rajender and Corey، نويسنده , , E.J.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2005
Abstract :
The COX-2 inhibitor rofecoxib (Vioxx™, 1) ionizes under physiological conditions to an anion that reacts readily with dioxygen to form inter alia the reactive maleic anhydride derivative 6, a potentially toxic compound.
Keywords :
COX-2 , ROFECOXIB , Inhibitor , Vioxx , Autoxidation , TOXICITY
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
