Title of article
A short practical synthesis of 2′-deoxymugineic acid
Author/Authors
Singh، نويسنده , , Satendra and Crossley، نويسنده , , George and Ghosal، نويسنده , , Saswati and Lefievre، نويسنده , , Yann and Pennington، نويسنده , , Michael W.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
3
From page
1419
To page
1421
Abstract
A short and practical synthesis of 2′-deoxymugineic acid (DMA) has been developed via reductive alkylation with the aldehyde intermediates. No protection of azetidine-2-carboxylic acid was required and the presence of free carboxylic acid function facilitated purification by simple acid and base extractions. Furthermore, the intermediates were conveniently purified by HPLC due to the presence of chromophoric benzyl ester protecting group(s). Hydrogenolysis of the benzyl protecting groups in the final step furnished DMA in overall good yield.
Keywords
DMA , 2?-Deoxymugineic acid , reductive alkylation , Reduced peptide bond
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1844887
Link To Document