Title of article
An efficient catalytic enantioselective fluorination of β-ketophosphonates using chiral palladium complexes
Author/Authors
Hamashima، نويسنده , , Yoshitaka and Suzuki، نويسنده , , Toshiaki and Shimura، نويسنده , , Yuta and Shimizu، نويسنده , , Tadashi and Umebayashi، نويسنده , , Natsuko and Tamura، نويسنده , , Toshihiro and Sasamoto، نويسنده , , Naoki and Sodeoka، نويسنده , , Mikiko، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
4
From page
1447
To page
1450
Abstract
On the basis of our Pd enolate chemistry, we have succeeded in developing an efficient catalytic enantioselective fluorination of β-ketophosphonates. In the presence of chiral Pd complexes 1 (1–10 mol %), various substrates including cyclic and acyclic β-ketophosphonates underwent the reaction with N-fluorobenzenesulfonimide (NFSI) in EtOH to give the corresponding fluorinated products in a highly enantioselective manner (94–98% ee).
Keywords
Pd complex , ?-Ketophosphonate , fluorination , Asymmetric catalysis
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1844904
Link To Document