Author/Authors :
Sunazuka، نويسنده , , Toshiaki and Yoshida، نويسنده , , Kiminari and Kojima، نويسنده , , Naoto and Shirahata، نويسنده , , Tatsuya and Hirose، نويسنده , , Tomoyasu and Handa، نويسنده , , Masaki and Yamamoto، نويسنده , , Daisuke and Harigaya، نويسنده , , Yoshihiro and Kuwajima، نويسنده , , Isao and ?mura، نويسنده , , Satoshi، نويسنده ,
Abstract :
Total synthesis of calabar bean alkaloid (−)-physovenine (−)-3 has been achieved in a concise manner starting from optically active (−)-3a-hydroxyfuroindoline (−)-2, synthesized via modified Sharpless epoxidation of tryptophol 1. Our strategy involved a stereospecific radical substitution reaction and regioselective oxidation at the C5 position.
