Author/Authors :
Cook، نويسنده , , James H. and Barzya، نويسنده , , Jeremy and Brennan، نويسنده , , Catherine H. Lowe، نويسنده , , Derek and Wang، نويسنده , , Yamin and Redman، نويسنده , , Anikَ and Scott، نويسنده , , William J. and Wood، نويسنده , , Jill E.، نويسنده ,
Abstract :
17β-Hydroxysteroid dehydrogenase II (17β-HSD II) antagonists may provide an important way into preventing the onset of osteoporosis. The discovery of 4,5-disubstituted cis-pyrrolidinones as 17β-HSD II inhibitors led to the development of an efficient intramolecular Michael addition, followed by catalytic hydrogenation to obtain the desired cis configuration.
Keywords :
Hydroxysteroid dehydrogenase , intramolecular Michael addition , 4 , 5-Disubstituted pyrrolidinones
