Title of article :
Novel erythromycin A derivatives: synthesis of 11,12-benzoxazine ketolides
Author/Authors :
Zhu، نويسنده , , Bin and Maden، نويسنده , , Amy and Macielag، نويسنده , , Mark J.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2005
Abstract :
A novel series of 11,12-benzoxazine ketolide derivatives of erythromycin A has been synthesized. The C11,C12-benzoxazine structure was constructed stereoselectively through an intramolecular Michael addition of a C12-O-(2-aminophenyl) group to the enone functionality of the 10,11-anhydro erythromycin A derivative 3.
Keywords :
Benzoxazine , macrolide , Antibacterial , Erythromycin , Ketolide
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
