Title of article :
Easy saponification by metal silanolates: application in SPPS and in (S)-5-hydroxynorvaline preparation
Author/Authors :
Daouda Minta، نويسنده , , Ewelina and Boutonnet، نويسنده , , Cédric and Boutard، نويسنده , , Nicolas and Martinez، نويسنده , , Jean-Paul Rolland، نويسنده , , Valérie، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2005
Abstract :
Alkali metal trimethylsilanolates, TMSO−, M+, has been used for efficient conversion of methyl esters into their corresponding anhydrous acid salts under mild non-aqueous conditions. This strategy has been applied to SPPS for the preparation of neurotoxin cyclic analogues and in (S)-5-hydroxynorvaline synthesis.
Keywords :
SPPS , Sodium and potassium silanolates , aminoacids , Glu , selective deprotection , ASP
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
