Author/Authors :
Ikemoto، نويسنده , , Norihiro and Miller، نويسنده , , Ross A. and Fleitz، نويسنده , , Fred J. and Liu، نويسنده , , Jinchu and Petrillo، نويسنده , , Daniel E. and Leone، نويسنده , , Joseph F. and Laquidara، نويسنده , , Joseph and Marcune، نويسنده , , Benjamin and Karady، نويسنده , , Sandor and Armstrong III، نويسنده , , Joseph D. and Volante، نويسنده , , Ralph P.، نويسنده ,
Abstract :
Two syntheses of the title compound 1 were developed based on different approaches for installing the oxazole ring moiety. Formation and dehydration of ketoamide was initially used and scaled up to afford 1 on several kilogram scale, then oxazolyl anion/iminium coupling reaction was developed for a more convergent approach.
Keywords :
Oxazole , Epoxide opening , protease inhibitor , Piperazine
