Title of article
A new route for the synthesis of indolizidine (−)-209D: excellent diastereoselectivity in the intramolecular hydroamination of alkynes
Author/Authors
Patil، نويسنده , , Nitin T. and Pahadi، نويسنده , , Nirmal K. and Yamamoto، نويسنده , , Yoshinori، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
3
From page
2101
To page
2103
Abstract
A highly efficient synthesis of indolizidine (−)-209D I has been accomplished. The key reaction in the synthesis is the palladium(0)/benzoic acid catalyzed intramolecular hydroamination of the ε-amino alkyne 6. The excellent diastereoselectivity in the intramolecular hydroamination is discussed on the basis of the proposed transition state.
Keywords
palladium catalyst , Hydroamination , Indolizidine 209D , Benzoic acid , alkaloid
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1845164
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