Author/Authors :
Zouhiri، نويسنده , , Fatima and Danet، نويسنده , , Michèle and Bénard، نويسنده , , Christophe and Normand-Bayle، نويسنده , , Marie and Mouscadet، نويسنده , , Jean-François and Leh، نويسنده , , Hervé and Marie Thomas، نويسنده , , Claire and Mbemba، نويسنده , , Gladys and d’Angelo، نويسنده , , Jean and Desmaële، نويسنده , , Didier، نويسنده ,
Abstract :
Novel variants of HIV-1 replication inhibitors of the styrylquinoline class, bearing an additional acid group or a propenoic acid moiety at the C-5 position of the quinoline have been synthesized. Key steps included Heck reaction and palladium catalyzed carbonylation reaction of 5-haloquinaldine derivatives. These compounds exhibited reinforced anti-integrase potency and significant antiviral activities.
Keywords :
carbonylation , Quinolines , antivirals , Enzyme inhibitors , Heck reactions
