Title of article
Direct access to CF3-propargyl amines and conversion to difluoromethyl imines
Author/Authors
Magueur، نويسنده , , Guillaume and Crousse، نويسنده , , Benoit and Bonnet-Delpon، نويسنده , , Danièle، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
3
From page
2219
To page
2221
Abstract
Trifluoromethyl aldimines reacted with acetylides in toluene at −78 °C to provide propargyl amines in good yields. From a chiral trifluoromethyl aldimine, the propargyl amines were obtained with excellent diastereoselectivities (de >98%). Trifluoromethyl propargyl amines could be further converted into difluoromethyl imines under basic conditions.
Keywords
Trifluoromethyl aldimines , Difluoromethyl imines , CF3-propargyl amines , Difluoromethyl propargyl amines
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1845206
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