Author/Authors :
Kuil، نويسنده , , Mark and Bekedam، نويسنده , , E. Koen and Visser، نويسنده , , Gerben M. and van den Hoogenband، نويسنده , , Adri and Terpstra، نويسنده , , Jan Willem and Kamer، نويسنده , , Paul C.J. and van Leeuwen، نويسنده , , Piet W.N.M. and van Strijdonck، نويسنده , , Gino P.F van Strijdonck، نويسنده ,
Abstract :
A highly efficient copper(I)-catalyzed N-arylation of azaheterocycles with various aryl halides is reported. The N-arylation reaction can be carried out using as low as 0.5 mol % of (Cu(I)OTf)2·PhH and 1.0 mol % of 4,7-dichloro-1,10-phenanthroline as the ligand. Furthermore, cheap and stable copper precursors like Cu(I)I and Cu(II)(OAc)2·H2O and the cheap and mild base K2CO3 can be used.
