Author/Authors :
Grant، نويسنده , , Eugene B. and Weiss، نويسنده , , Jesse M. and Branum، نويسنده , , Shawn and Hayden، نويسنده , , Stuart K. Johnson، نويسنده , , Sigmond and Guiadeen، نويسنده , , Deodialsingh and Murray، نويسنده , , William V. and Macielag، نويسنده , , Mark J.، نويسنده ,
Abstract :
A short, concise synthesis of a novel series of (9S)-9-alkyl-9-hydroxyerythromycin A derivatives and their corresponding ketolides, is described. The key chemical transformation is a stereoselective addition of organomagnesium or organolithium agents to the 9-position of the suitably protected macrolide templates 8 and 13.
