Title of article
Water-based biphasic media for exothermic reactions: green chemistry strategy for the large scale preparation of clofibric acid and analogues
Author/Authors
Bose، نويسنده , , Ajay K. and Manhas، نويسنده , , Maghar S. and Ganguly، نويسنده , , Subhendu N. and Pednekar، نويسنده , , Suhas and Mandadi، نويسنده , , Arun، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
3
From page
3011
To page
3013
Abstract
A water-based biphasic reaction process has been developed for conducting exothermic reactions without organic solvents. This procedure is rapid, simple, and suitable for small scale synthesis as well as larger (multi-molar) scale reactions. The preparation of several hundred grams of clofibric acid and analogues by this eco-friendly and energy-efficient procedure is described. Smaller amounts of these compounds were prepared by the friction-activated ‘Grindstone Chemistry’ method described previously.
Keywords
2-Methyl-2-aryloxypropanoic acids , Exothermic Reaction , Water-based biphasic reaction media , Energy-efficient process , Clofibric acid
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1845484
Link To Document