Title of article
First example of base-promoted tandem alkylation–bromination of 2-bromothiophene via halogen dance process: a remarkable temperature effect
Author/Authors
Peyron، نويسنده , , Corinne and Navarre، نويسنده , , Jean-Michel and Van Craynest، نويسنده , , Nathalie and Benhida، نويسنده , , Rachid، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
4
From page
3315
To page
3318
Abstract
Metalation–alkylation of 2-bromothiophene 1 when conducted at low temperature led to the 5-alkylated 2-bromo products 2. While, at room temperature, the same sequential reactions afforded the original dibromo-alkylated thiophenes 3 following an unprecedented halogen transfer-based halogen dance process in highly regiocontrolled and ordered way.
Keywords
Tandem process , halogen dance , X-philic reaction , Regiocontrolled halogen transfer cascade
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1845593
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