A new method for stereoselective oxidation of chiral 2-pyrrolidino-1-ethanol derivatives to oxazolopyrrolidines using trimethylamine-N-oxide in the presence of iron carbonyls

Chiral 2-pyrrolidino-1-ethanol derivatives were oxidatively cyclized to the corresponding oxazolopyrrolidines, with excellent stereoselectivity by treatment with excess Me3NO in the presence of 20% of an iron carbonyl complex.