Title of article :
High throughput screening of O-glycosylation conditions
Author/Authors :
Ishiwata، نويسنده , , Akihiro and Ito، نويسنده , , Yukishige، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2005
Abstract :
We report a novel methodology for rapid and quantitative screening of O-glycosylation reactions of application to the analysis of parallel reaction systems. Our system exploits perdeuterated benzyl (Bn-d7) ether, and stereoselectivity and yield are evaluated by 1H NMR and MALDI-TOF MS, respectively. This paper summarizes over 240 screenings of 1 → 3 linkage formation between glucose residues targeting the α-isomer in high yield.
Keywords :
Stereoselective glycosylation , Rapid and quantitative screening , Deuterium-labeled compound , MALDI-TOF MS , 1H NMR
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
