Title of article
High throughput screening of O-glycosylation conditions
Author/Authors
Ishiwata، نويسنده , , Akihiro and Ito، نويسنده , , Yukishige، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
4
From page
3521
To page
3524
Abstract
We report a novel methodology for rapid and quantitative screening of O-glycosylation reactions of application to the analysis of parallel reaction systems. Our system exploits perdeuterated benzyl (Bn-d7) ether, and stereoselectivity and yield are evaluated by 1H NMR and MALDI-TOF MS, respectively. This paper summarizes over 240 screenings of 1 → 3 linkage formation between glucose residues targeting the α-isomer in high yield.
Keywords
Stereoselective glycosylation , Rapid and quantitative screening , Deuterium-labeled compound , MALDI-TOF MS , 1H NMR
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1845661
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