Title of article
A one-pot synthesis of nitrogen-containing heteroaryl α-keto amides from heteroaryl halides
Author/Authors
Zhu، نويسنده , , Juliang and Wong، نويسنده , , Henry and Zhang، نويسنده , , Zhongxing and Yin، نويسنده , , Zhiwei and Kadow، نويسنده , , John F. and Meanwell، نويسنده , , Nicholas A. and Wang، نويسنده , , Tao، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
3
From page
3587
To page
3589
Abstract
The SNAr-type reaction of the piperidine amide of cyanoacetic acid with a series of heteroaryl halides followed by in situ oxidation of the resultant anion with peracetic acid provided a convenient, one-pot protocol for preparative access to heteroaryl α-keto amides. In this procedure, the amide of cyanoacetic acid functions as an Umpolung-type synthon of the α-keto amide moiety.
Keywords
Acyl carbanion equivalent , Condensation–oxidation , ?-Cyano acetamide , Heteroaryl ?-keto amide
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1845698
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