Title of article :
Conformational studies and solution structure of laulimalide and simplified analogues using NMR spectroscopy and molecular modelling
Author/Authors :
Paterson، نويسنده , , Ian and Menche، نويسنده , , Dirk and Britton، نويسنده , , Robert and H?kansson، نويسنده , , Anders E. and Silva-Mart??nez، نويسنده , , Mar??a ?.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2005
Abstract :
The solution structures of the potent microtubule-stabilizing anti-cancer agent laulimalide and simplified analogues were determined by a combination of high field 1H NMR spectroscopic studies (J-based configuration analysis and NOESY) and constrained molecular dynamics simulations and discussed in relation to their antiproliferative activity.
Keywords :
conformational analysis , Analogues , solution structure , Laulimalide , Anti-cancer agent , Modelling
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
