Author/Authors :
Gug، نويسنده , , Fabienne and Blondel، نويسنده , , Marc and Desban، نويسنده , , Nathalie and Bouaziz، نويسنده , , Serge and Vierfond، نويسنده , , Jean-Michel and Galons، نويسنده , , Hervé، نويسنده ,
Abstract :
A simple synthesis of biologically active 6-aminophenanthridines was achieved by a Suzuki–Miyaura coupling reaction. Condensation of 2-(4,4,5,5-tetramethyl-1,3-dioxaborolan-2-yl)aniline with 2-chlorobenzonitriles afforded 6-aminophenanthridines useful as prions inhibitors in a mild one-step procedure. The intermediate 2-amino-2′cyanobiphenyls could not be isolated.
