Title of article :
Structural elucidation of the β-turn inducing (S)-[3-amino-4-oxo-2,3-dihydro-5H-benzo[b][1,4]thiazepin-5-yl] acetic acid (DBT) motif
Author/Authors :
Amblard، نويسنده , , Muriel and Raynal، نويسنده , , Nicolas and Averlant-Petit، نويسنده , , Marie-Christine and Didierjean، نويسنده , , Claude and Calmès، نويسنده , , Monique and Fabre، نويسنده , , Olivier and Aubry، نويسنده , , André and Marraud، نويسنده , , Michel and Martinez، نويسنده , , Jean، نويسنده ,
Abstract :
X-ray diffraction analysis of Boc-DBT-NH2 (DBT = (S-[amino]-5-carbethoxymethyl-2,3-dihydro-1,5-benzothiazepine-4(5H)-one) showed that this constrained dipeptide mimetic adopts a type II′ β-turn in the solid state. IR and NMR studies indicated that the folded conformation is retained in solution.
Keywords :
Benzothiazepine-4(5H)-one derivative , ?-turn mimetic , crystal structure , IR study , NMR study
