Title of article
Regioselective synthesis of 1-arylindazoles via N-arylation of 3-trimethylsilylindazoles
Author/Authors
Hari، نويسنده , , Robert Yoshiyuki and Shoji، نويسنده , , Yoshimichi and Aoyama، نويسنده , , Toyohiko، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
4
From page
3771
To page
3774
Abstract
The copper(II)-catalyzed cross-coupling reaction of 3-trimethylsilylindazoles bearing substituents on the benzene ring with arylboronic acids regioselectively gave the corresponding 1-aryl-3-trimethylsilylindazoles and no 2-aryl isomers were formed at all. Moreover, the trimethylsilyl group of the resulting indazoles was easily removed by treatment with ethanolic KOH to give 1-arylindazoles.
Keywords
N-Arylation , Arylboronic acid , indazoles , regioselectivity , Silyl compounds
Journal title
Tetrahedron Letters
Serial Year
2005
Journal title
Tetrahedron Letters
Record number
1845771
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