Title of article :
New methodology for 2-alkylation of 3-furoic acids: application to the synthesis of tethered UC-781/d4T bifunctional HIV reverse-transcriptase inhibitors
Author/Authors :
Arnott، نويسنده , , Gareth and Hunter، نويسنده , , Roger and Mbeki، نويسنده , , Linda and Mohamed، نويسنده , , Ebrahim، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2005
Abstract :
New methodology for 2-alkylation of 3-furoic acids is presented involving Wittig reactions of the 3-methoxycarbonyl-2-furanylmethylphosphonium salt. The methodology has been used to prepare a tethered 2-alkylated-UC-781/d4T conjugate as a potentially new type of HIV reverse-transcriptase inhibitor.
Keywords :
Bifunctional HIV reverse-transcriptase inhibitors , Furan alkylation , Wittig reaction of 2-furanylphosphonium salt , Alkylated-UC-781
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
