Author/Authors :
Niida، نويسنده , , Ayumu and Oishi، نويسنده , , Shinya and Sasaki، نويسنده , , Yoshikazu and Mizumoto، نويسنده , , Makiko and Tamamura، نويسنده , , Hirokazu and Fujii، نويسنده , , Nobutaka and Otaka، نويسنده , , Akira، نويسنده ,
Abstract :
Regio- and stereoselective anti-SN2′ alkylation of γ-phosphoryloxy-α,β-unsaturated-δ-lactams with organocopper reagents allowing the preparation of N-alkylated-α,δ-substituted-β,γ-unsaturated-δ-lactams as highly functionalized diketopiperazine mimetics is presented.
Keywords :
Organocopper , Phosphate , anti-SN2? reaction , Peptidomimetic
